Trainor, George: search on Z-Library

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1

The importance of plasma protein binding in drug discovery

Trainor, George L

Journal:

Expert Opinion on Drug Discovery

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

2

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors

Li, Guo, Meanwell, Nicholas A., Krystal, Mark R., Langley, David R., Naidu, B. Narasimhulu, Sivaprakasam, Prasanna, Lewis, Hal, Kish, Kevin, Khan, Javed A., Ng, Alicia, Trainor, George L., Cianci, Chr

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 3.60 MB

english, 2020

3

Book reviews

Zahedieh, Nuala, Williams, Glyndwr, Marshall, P.J., Rich, Paul B., Shaw, A.G.L., Trainor, Luke, Latham, Martin, Shepperson, George, Stevenson, David, Ballhatchet, Kenneth, Dilks, David N., Millar, T.B

Journal:

The Journal of Imperial & Commonwealth History

Year:

1988

Language:

english

File:

PDF, 1.32 MB

english, 1988

4

Preparation and structure-activity relationships of simplified analogs of the antifungal agent cilofungin: a total synthesis approach

Zambias, Robert A., Hammond, Milton L., Heck, James V., Bartizal, Ken, Trainor, Charlotte, Abruzzo, George, Schmatz, Dennis M., Nollstadt, Karl M.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.73 MB

english, 1992

5

Identification and Treatment of Retinopathy of Prematurity: An Update and Review

WHITE, GEORGE L., TRAINOR, SUSAN F., KIVLIN, JANE D., WOOD, STEPHEN D.

Journal:

Southern Medical Journal

Year:

1991

File:

PDF, 355 KB

1991

6

The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear

Cao, Chike, Oswald, Aaron B., Fabella, Brian A., Ren, Yinshi, Rodriguiz, Ramona, Trainor, George, Greenblatt, Matthew B., Hilton, Matthew J., Pitt, Geoffrey S.

Journal:

Year:

2019

File:

PDF, 1.93 MB

2019

7

An organotransition metal based approach to the synthesis of C-glycosides

DeShong, Philip, Slough, Greg A., Elango, Varadaraj, Trainor, George L.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 339 KB

english, 1985

8

Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)

Balkovec, James M., Black, Regina M., Hammond, Milton L., Heck, James V., Zambias, Robert A., Abruzzo, George, Bartizal, Ken, Kropp, Helmut, Trainor, Charlotte

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 718 KB

english, 1992

9

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer

Huang, Audris, Jayaraman, Lata, Fura, Aberra, Vite, Gregory D., Trainor, George L, Gottardis, Marco M, Spires, Thomas E, Spires, Vanessa M, Rizzo, Cheryl A, Obermeier, Mary, Elzinga, Paul A, Todderud,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 615 KB

english, 2015

10

Synthesis and Evaluation of Efavirenz (SustivaTM) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain

Anthony J. Cocuzza, Dennis R. Chidester, Beverly C. Cordova, Susan Jeffrey, Rodney L. Parsons, Lee T. Bacheler, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 102 KB

english, 2001

11

Synthesis and evaluation of analogs of Efavirenz (SUSTIVATM) as HIV-1 reverse transcriptase inhibitors

Mona Patel, Soo S. Ko, Robert J. McHugh Jr., Jay A. Markwalder, Anurag S. Srivastava, Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, George L. Trainor, Steven.P. Seitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 279 KB

english, 1999

12

Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening

Posy, Shana L., Hermsmeier, Mark A., Vaccaro, Wayne, Ott, Karl-Heinz, Todderud, Gordon, Lippy, Jonathan S., Trainor, George L., Loughney, Deborah A., Johnson, Stephen R.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 6.71 MB

english, 2011

13

Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors

Mona Patel, Robert J McHugh Jr., Beverly C Cordova, Ronald M Klabe, Susan Erickson-Viitanen, George L Trainor, James D Rodgers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 132 KB

english, 2000

14

-Trifluoromethyl Carbohydrates

Trainor, George L.

Journal:

Journal of Carbohydrate Chemistry

Year:

1985

Language:

english

File:

PDF, 702 KB

english, 1985

15

Genetic Bit Analysis: a solid phase method for typing single nucleotide polymorphisms

Nikiforov, Theo T., Rendie, Robert B., Goelet, Philip, Rogers, Yu-Hui, Kotewicz, Michael L., Anderson, Stephen, Trainor, George L., Knapp, Michael R.

Journal:

Nucleic Acids Research

Year:

1994

Language:

english

File:

PDF, 4.61 MB

english, 1994

16

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck, Argyrios G. Arvanitis, Matt A. Curry, Joseph T. Rescinito, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 300 KB

english, 1999

17

Modulation of cofilin phosphorylation by inhibition of the Lim family kinases

He, Liqi, Seitz, Steven P., Trainor, George L., Tortolani, David, Vaccaro, Wayne, Poss, Michael, Tarby, Christine M., Tokarski, John S., Penhallow, Becky, Hung, Chen-Yi, Attar, Ricardo, Lin, Tai-An

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 600 KB

english, 2012

18

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVATM)

Mona Patel, Robert J. McHugh Jr., Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 181 KB

english, 1999

19

Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck, Matt A. Curry, Robert J. Chorvat, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 219 KB

english, 1999

20

High incidence of congenital dislocation of the hip in Northern Ireland

Christopher C. Patterson, W. George Kernohan, RAB Mollan, Pauline E. Haugh, Bernadette P. Trainor

Journal:

Paediatric and Perinatal Epidemiology

Year:

1995

Language:

english

File:

PDF, 450 KB

english, 1995

21

Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation

Sielecki, Thais M., Boylan, John F., Benfield, Pamela A., Trainor, George L.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 599 KB

english, 2000

22

Strengthening Ontario's System of Housing for People with Serious Mental Illness

Sylvestre, John, George, Lindsey, Aubry, Tim, Durbin, Janet, Nelson, Geoffrey, Trainor, John

Journal:

Canadian Journal of Community Mental Health

Year:

2007

Language:

english

File:

PDF, 90 KB

english, 2007

23

Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA

Soong-Hoon Kim, John S. Tokarski, Kenneth J. Leavitt, Brian E. Fink, Mark E. Salvati, Robert Moquin, Mary T. Obermeier, George L. Trainor, Gregory G. Vite, Linda K. Stadnick, Jonathan S. Lippy, Dan Yo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 289 KB

english, 2008

24

The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear

Cao, Chike, Oswald, Aaron B., Fabella, Brian A., Ren, Yinshi, Rodriguiz, Ramona, Trainor, George, Greenblatt, Matthew B., Hilton, Matthew J., Pitt, Geoffrey S.

Journal:

Year:

2019

Language:

english

File:

PDF, 1.93 MB

english, 2019

25

Chirality transfer to iron in a photochemical reaction of a glucopyranosyliron compound

George L. Trainor

Journal:

Journal of Organometallic Chemistry

Year:

1985

Language:

english

File:

PDF, 213 KB

english, 1985

26

Preface

George L. Trainor

Journal:

Perspectives in Drug Discovery and Design

Year:

1996

Language:

english

File:

PDF, 116 KB

english, 1996

27

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)pyrazolo[1,5- a ]-1,3,5-triazine: A Potent, Orally Bioavailable CRF 1 Receptor Antagonist

He, Liqi, Gilligan, Paul J., Zaczek, Robert, Fitzgerald, Lawrence W., McElroy, John, Shen, H-S. L., Saye, Jo Anne, Kalin, Ned H., Shelton, Steven, Christ, David, Trainor, George, Hartig, Paul

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 98 KB

english, 2000

28

ChemInform Abstract: Synthesis and Evaluation of Benzoxazinones as HIV-1 Reverse Transcriptase Inhibitors. Analogues of Efavirenz (Sustiva).

Mona Patel, Robert J. McHugh Jr., Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Year:

2000

File:

PDF, 36 KB

2000

29

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)

Tram Huynh, Zhong Chen, Suhong Pang, Jieping Geng, Tiziano Bandiera, Simona Bindi, Paola Vianello, Fulvia Roletto, Sandrine Thieffine, Arturo Galvani, Wayne Vaccaro, Michael A. Poss, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 548 KB

english, 2009

30

[Part 2: Physical Sciences] || Evidence for the General Base Mechanism in Carboxypeptidase A-Catalyzed Reactions: Partitioning Studies on Nucleophiles and H218O Kinetic Isotope Effects

Ronald Breslow, Jik Chin, Donald Hilvert and George Trainor

Journal:

Proceedings of the National Academy of Sciences

Year:

1983

Language:

english

File:

PDF, 968 KB

english, 1983

31

Introduction modified oligonucleotides

George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 73 KB

english, 1994

32

Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease

Chien-An Chen, Scott McN Sieburth, Athanasios Glekas, Gregory W Hewitt, George L Trainor, Susan Erickson-Viitanen, Sena S Garber, Beverly Cordova, Susan Jeffry, Ronald M Klabe

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 328 KB

english, 2001

33

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones

Jovita Marcinkeviciene, M.John Rogers, Lisa Kopcho, Wenjun Jiang, Kathy Wang, Dennis J Murphy, Jonathan Lippy, Steven Link, Thomas D.Y Chung, Frank Hobbs, Tasir Haque, George L Trainor, Andrew Slee, A

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 229 KB

english, 2000

34

ChemInform Abstract: NUCLEAR MAGNETIC RESONANCE SPECTRAL STUDIES PART 8, TITANIUM TETRACHLORIDE AS A SHIFT REAGENT

BOSE, AJAY K., SRINIVASAN, P. R., TRAINOR, GEORGE

Journal:

Chemischer Informationsdienst

Year:

1974

File:

PDF, 99 KB

1974

35

ChemInform Abstract: Synthesis and Evaluation of Efavirenz (Sustiva) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain.

Anthony J. Cocuzza, Dennis R. Chidester, Beverly C. Cordova, Susan Jeffrey, Rodney L. Parsons, Lee T. Bacheler, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Year:

2001

Language:

english

File:

PDF, 34 KB

english, 2001

36

The synthesis and antitumor evaluation of unsymmetrical bis-imides

Robert J. Cherney, Stephen G. Swartz, Arthur D. Patten, Emeka Akamike, Jung-Hui Sun, Robert F. Kaltenbach III, Steven P. Seitz, Carl H. Behrens, Zelleka Getahun, George L. Trainor, Mike Vavala, Mindy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 272 KB

english, 1997

37

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors

James D. Rodgers, Patrick Y.S. Lam, Barry L. Johnson, Haisheng Wang, Soo S. Ko, Steven P. Seitz, George L. Trainor, Paul S. Anderson, Ronald M. Klabe, Lee T. Bacheler, Beverly Cordova, Sena Garber, Ca

Journal:

Chemistry & Biology

Year:

1998

File:

PDF, 33 KB

1998

38

Oligonucleotides with a nuclease-resistant sulfur-based linkage

Huie, Edward M., Kirshenbaum, Mindy R., Trainor, George L.

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 348 KB

english, 1992

39

ChemInform Abstract: Thiazolo[4,5-d]pyrimidine Thiones and -ones as Corticotropin-Releasing Hormone (CRH-R1) Receptor Antagonists.

James P. Beck, Matt A. Curry, Robert J. Chorvat, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Year:

1999

File:

PDF, 33 KB

1999

40

Discovery and Structure−Activity Relationship of N-(Ureidoalkyl)-Benzyl-Piperidines As Potent Small Molecule CC Chemokine Receptor-3 (CCR3) Antagonists

De Lucca, George V., Kim, Ui T., Johnson, Curt, Vargo, Brian J., Welch, Patricia K., Covington, Maryanne, Davies, Paul, Solomon, Kimberly A., Newton, Robert C., Trainor, George L., Decicco, Carl P., K

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 202 KB

english, 2002

41

High acylation rates and enantioselectivity with cyclodextrin complexes of rigid substrates

Trainor, George L., Breslow, Ronald

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 761 KB

english, 1981

42

Optimization of metallocene substrates for .beta.-cyclodextrin reactions

Breslow, Ronald, Trainor, George, Ueno, Akihiko

Journal:

Journal of the American Chemical Society

Year:

1983

Language:

english

File:

PDF, 814 KB

english, 1983

43

Synthesis of Reagents for Fluorescence-Tagging of DNA

Trainor, George, Hobbs, Frank, Cocuzza, Anthony, Confalone, Pat

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

1989

Language:

english

File:

PDF, 254 KB

english, 1989

44

Cost‐Benefit Appraisal of Screening for Congenital Dislocation of the Hip

Kernohan, W. George, Trainor, Bernadette P., Mollan, Raynold A.B., Normand, Charles E.M.

Journal:

Journal of Management in Medicine

Year:

1990

Language:

english

File:

PDF, 348 KB

english, 1990

45

Inorganic Ligand Effects on Pb(II) Sorption to Goethite (α-FeOOH): I. Carbonate

John D. Ostergren, Thomas P. Trainor, John R. Bargar, Gordon E. Brown Jr., George A. Parks

Journal:

Journal of Colloid and Interface Science

Year:

2000

Language:

english

File:

PDF, 408 KB

english, 2000

46

Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies

Honghe Wan, Tram Huynh, Suhong Pang, Jieping Geng, Wayne Vaccaro, Michael A. Poss, George L. Trainor, Matthew V. Lorenzi, Marco Gottardis, Lata Jayaraman, Ashok V. Purandare

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

47

Preclinical antitumor activity of XK469 (NSC 656889)

Patricia M LoRusso, Ralph Parchment, Lisa Demchik, Juianna Knight, Lisa Polin, Janet Dzubow, Carl Behrens, Barbara Harrison, George Trainor, Thomas H. Corbett

Journal:

Investigational New Drugs

Year:

1998

Language:

english

File:

PDF, 108 KB

english, 1998

48

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 42 Volume 42 || Chapter 31 Plasma Protein Binding and the Free Drug Principle: Recent Developments and Applications

Trainor, George L.

Year:

2007

Language:

english

File:

PDF, 138 KB

english, 2007

49

Cholesterol Enhances Helicobacter pylori Resistance to Antibiotics and LL-37

McGee, D. J., George, A. E., Trainor, E. A., Horton, K. E., Hildebrandt, E., Testerman, T. L.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2011

Language:

english

File:

PDF, 1.79 MB

english, 2011

50

ChemInform Abstract: Purin-8-ones as Corticotropin-Releasing Hormone (CRH-R1) Receptor Antagonists.

James P. Beck, Argyrios G. Arvanitis, Matt A. Curry, Joseph T. Rescinito, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Year:

1999

File:

PDF, 30 KB

1999

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